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Use of dopexamine hydrochloride in patients with septic shock
F C Colardyn1, J F Vandenbogaerde, D P Vogelaers
1Department of Intensive Care, University Hospital, State University, Gent, Belgium.
Critical Care Medicine
|October 1, 1989
Abstract:
The short and long-term hemodynamic effects of iv dopexamine hydrochloride (DPX) were studied in ten patients with septic shock. In the short-term study, a dose-dependent increase in cardiac index and heart rate, and a dose-dependent decrease in systemic vascular resistance were demonstrated. These effects diminished gradually during the long-term study, suggesting a problem of tolerance. Although the administration of DPX during septic shock appeared to be relatively safe, its hemodynamic effects suggest that it may be more indicated in selected patients with a low cardiac output.