Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine
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Updated: Mar 10, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
U Sailaja1, M Shahin Thayyil2, N S Krishna Kumar3
1Department of Physics, M.E.S Keveeyam College, Valanchery, 676 552 Malappuram, Kerala, India.
Abstract:
The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.
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