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Pharmacokinetics of miocamycin in patients with liver cirrhosis
P A Miglioli1, P Pivetta, R Orlando
1Department of Pharmacology, University of Padua, Italy.
Chemotherapy
|January 1, 1989
Abstract:
The pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these patients.