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The correlation between lymphocyte/monocyte ratio and coronary collateral circulation in stable coronary artery

Alparslan Kurtul1, Mustafa Duran1

  • 1Department of Cardiology, Ankara Education & Research Hospital, Ankara, Turkey.

Biomarkers in Medicine
|December 6, 2016
PubMed

Insights

The lymphocyte-to-monocyte ratio (LMR) is higher in patients with good coronary collateral circulation (CCC). Increased LMR is a predictor of well-developed CCC in stable coronary artery disease (SCAD) patients.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Coronary collateral circulation (CCC) significantly impacts cardiovascular prognosis.
  • Well-developed CCC is linked to improved clinical outcomes in patients with coronary artery disease.

Purpose of the Study:

  • To investigate the association between the lymphocyte-to-monocyte ratio (LMR) and CCC in patients with stable coronary artery disease (SCAD).

Main Methods:

  • The study included 245 SCAD patients.
  • Patients were categorized into poor CCC (Rentrop grades 0/1) and good CCC (Rentrop grades 2/3) groups.

Main Results:

  • LMR was significantly higher in the good CCC group (4.41 ± 1.58) compared to the poor CCC group (2.76 ± 1.10).
  • An LMR cutoff of 3.38 predicted well-developed CCC.
  • Multivariate analysis identified LMR >3.38 as an independent predictor of well-developed CCC.

Conclusions:

  • Elevated LMR is associated with well-developed coronary collateral circulation in SCAD patients.
Abstract

Keywords:
coronary atherosclerosiscoronary collateral circulationinflammationlymphocytelymphocyte/monocyte ratiomonocytestable coronary artery disease

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