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Related Experiment Video

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A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Bone loss & platelet-to-lymphocyte ratio.

Sezen Bozkurt Koseoglu¹

¹Department of Gynecology & Obstetrics, Mugla Sitki Kocman Training & Research Hospital, Mugla, Turkey.

Biomarkers in Medicine

|December 6, 2016

Summary

The platelet-to-lymphocyte ratio (PLR) may help predict low bone mineral density (BMD) in postmenopausal women. Higher PLR levels were observed in women with low BMD, suggesting its potential as a predictive biomarker.

Keywords:

absorptiometry bone loss bone mineral density dual x-ray low-density lipoprotein cholesterol osteoporosis postmenopause

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Area of Science:

Endocrinology
Hematology
Orthopedics

Background:

Postmenopausal osteoporosis is a significant health concern.
Biomarkers for early detection of low bone mineral density (BMD) are needed.
Inflammatory markers are increasingly investigated for their role in bone health.

Purpose of the Study:

To investigate the association between platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet ratio (NPR), and low-density lipoprotein cholesterol (LDL-C) with low BMD in postmenopausal women.
To determine if PLR can serve as a predictive factor for low BMD.

Main Methods:

Retrospective analysis of electronic records from 211 postmenopausal women.
Patients were categorized into control (n=32) and low BMD (n=179) groups based on T-scores.
Statistical analysis including receiver operating characteristic (ROC) analysis was performed.

Main Results:

Platelet-to-lymphocyte ratio (PLR) was significantly higher in the low BMD group compared to the control group.
ROC analysis identified PLR as a significant discriminative factor for identifying low BMD.
No significant association was found for NPR or LDL-C with low BMD (implied by focus on PLR in results).

Conclusions:

Elevated PLR may serve as a potential predictor of low bone mineral density in postmenopausal women.
Baseline PLR measurement could aid in the early identification of women at risk for osteoporosis.
Further prospective studies are warranted to confirm these findings and explore underlying mechanisms.