Related Experiment Video
Updated: Mar 10, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Pediatric disorders of pigmentation commonly seen in skin of color
1Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Insights
Accurate diagnosis of hyperpigmentation and hypopigmentation disorders in children with skin of color is crucial for timely treatment. This review aids physicians in identifying common pediatric pigmentary conditions, improving patient outcomes.
Area of Science:
- Pediatric Dermatology
- Dermatology
- Genetics
Background:
- Pigmentary disorders, including hyperpigmentation and hypopigmentation, present unique challenges in children with skin of color.
- Accurate and timely diagnosis is essential to prevent treatment delays and improve quality of life for affected children.
- The varied etiologies and similar clinical presentations of pigmentary disorders necessitate specialized diagnostic skills.
Purpose of the Study:
- To review common disorders of hyperpigmentation and hypopigmentation in pediatric patients with skin of color.
- To equip physicians with knowledge for enhanced clinical detection of these pigmentary conditions.
- To address the specific needs of a vulnerable pediatric population with skin of color.
Main Methods:
- Literature review of common pediatric pigmentary disorders.
- Analysis of clinical presentations and diagnostic criteria.
- Focus on conditions prevalent in children with skin of color.
Main Results:
- Identification of key hyperpigmentary and hypopigmentary disorders common in children with skin of color.
- Discussion of differential diagnoses and diagnostic pearls.
- Emphasis on the importance of early and accurate diagnosis for effective management.
Conclusions:
- Physicians require specific knowledge to accurately diagnose pigmentary disorders in children with skin of color.
- Enhanced clinical detection strategies can significantly improve patient care and outcomes.
- This review serves as a valuable resource for clinicians managing pediatric pigmentary conditions.
Abstract:
There are certain disorders of hyper- and hypopigmentation that are more common in children with skin of color. It is imperative that practitioners can swiftly and accurately diagnose these pigmentary disorders to prevent delay in treatment and enhance quality of life. Pigmentary disorders have many etiologies and may present similarly in the clinical setting; however treatment varies widely and is dependent on accurate diagnosis. Herein, we present a review of common disorders of hyperpigmentation and hypopigmentation in children with skin of color. We aim to provide physicians with information that can enhance clinical detection of common pigmentary disorders in this vulnerable population.
Related Concept Videos
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pleiotropy
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism

