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Pentamidine-associated pancreatitis.

M S Schwartz¹, M S Cappell

¹Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.

Digestive Diseases and Sciences

|October 1, 1989

Summary

This summary is machine-generated.

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Pentamidine isethionate therapy for Pneumocystis carinii pneumonia can cause acute pancreatitis in patients with acquired immunodeficiency syndrome. Early warning signs include glucose abnormalities and abdominal pain.

Area of Science:

Pharmacology
Infectious Diseases
Gastroenterology

Background:

Pneumocystis carinii pneumonia (PCP) is a common opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS).
Pentamidine isethionate is a primary treatment for PCP.
Acute pancreatitis is a serious condition with various potential causes.

Observation:

Two patients with AIDS and PCP developed acute pancreatitis shortly after starting pentamidine isethionate treatment.
Pancreatitis symptoms resolved upon discontinuation of the medication.
One patient tolerated inhaled pentamidine without recurrence.

Findings:

Pentamidine-associated pancreatitis can occur in patients without prior risk factors.
The condition typically manifests within three weeks of therapy initiation and after a cumulative dose exceeding 1 gram.

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Potential early indicators include glucose abnormalities, renal insufficiency, and non-specific abdominal pain.

Implications:

Clinicians should consider pentamidine-induced pancreatitis in AIDS patients presenting with compatible symptoms.
Monitoring for glucose and renal function may aid in early detection.
Alternative treatment strategies or careful monitoring may be necessary for patients requiring pentamidine therapy.