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Androgen Receptor: A Complex Therapeutic Target for Breast Cancer

Ramesh Narayanan1, James T Dalton2

  • 1Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA. rnaraya4@uthsc.edu.

Cancers
|December 6, 2016
PubMed

Insights

Androgen receptor (AR) is emerging as a key target for breast cancer treatment, especially in resistant cases. This review explores the complex therapeutic role of AR, including new drug developments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are primary breast cancer targets.
  • Androgen receptor (AR) is increasingly recognized for its role in treatment-resistant breast cancer.
  • High AR expression in breast tumors supports its investigation as a therapeutic target.

Approach:

  • This review synthesizes current research on the androgen receptor's function in breast cancer.
  • It examines the rationale for targeting AR, including novel nonsteroidal drugs.
  • The review discusses the complexities of AR agonism and antagonism in clinical trials.

Key Points:

  • AR is a promising target for overcoming resistance to conventional breast cancer therapies.
  • New nonsteroidal drugs targeting AR are in clinical development.
  • The dual role of AR agonists and antagonists presents a complex therapeutic landscape.

Conclusions:

  • Understanding the intricate role of AR is crucial for developing effective precision treatments for breast cancer.
  • Further research into AR-targeted therapies may offer new options for patients with advanced or resistant disease.
Keywords:
androgen receptorbreast cancerestrogen receptorselective androgen receptor modulator (SARM)triple-negative breast cancer (TNBC)

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