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Related Experiment Videos

Variability in clinically measured photopic oscillatory potentials.

A C Kothe1, J V Lovasik, S G Coupland

  • 1University of Waterloo, School of Optometry, Ontario, Canada.

Documenta Ophthalmologica. Advances in Ophthalmology
|April 1, 1989
PubMed
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Photopic oscillatory potentials (OPs) in electroretinograms show high variability in amplitude, even under controlled conditions. Implicit times, not amplitudes, are recommended for clinical neurophysiology measurements in diabetic retinopathy.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Physiology

Background:

  • Oscillatory potentials (OPs) on the electroretinogram (ERG) b-wave originate in the inner plexiform layer.
  • OPs are sensitive to retinal blood flow changes, aiding diabetic retinopathy ischemia assessment.

Purpose of the Study:

  • To investigate the significant intra- and inter-subject variability of photopic OPs.
  • To determine reliable measurement parameters for clinical neurophysiology in diabetic retinopathy.

Main Methods:

  • Repeated measures of photopic oscillatory potentials under tightly controlled laboratory conditions.
  • Analysis of amplitude variability in five light-adapted wavelets.

Main Results:

  • Significant, previously unreported variability in photopic OP amplitudes was observed.

Related Experiment Videos

  • Considerable intra- and inter-subject variability in wavelet amplitudes was found.

    • Conclusions:

    • Current OP amplitude measurements exhibit high variability, limiting clinical utility.
    • Oscillatory potential implicit times are a more stable and reliable metric than amplitudes for clinical neurophysiology in diabetic retinopathy.