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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Chemical Synapses01:26

Chemical Synapses

12.2K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Chemical Synapses01:26

Chemical Synapses

6.2K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Related Experiment Video

Updated: Mar 10, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

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Autoimmune choreas.

Francisco Cardoso

    Journal of Neurology, Neurosurgery, and Psychiatry
    |December 6, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Autoimmune processes can cause chorea, a movement disorder. This review covers the epidemiology, features, pathogenesis, and management of common autoimmune causes like Sydenham's chorea and lupus.

    Keywords:
    HUNTINGTON'SIMMUNOLOGYINFECTIOUS DISEASESLUPUS ANTICOAGULANTMOVEMENT DISORDERS

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    Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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    Area of Science:

    • Neurology
    • Immunology
    • Genetics

    Background:

    • Chorea is a movement disorder with diverse genetic and non-genetic origins.
    • Autoimmune conditions are infrequent but significant causes of chorea in both research and clinical settings.

    Purpose of the Study:

    • To review the epidemiology, clinical and laboratory features, pathogenesis, and management of common autoimmune etiologies of chorea.
    • To highlight specific conditions including Sydenham's chorea, systemic lupus erythematosus, primary antiphospholipid antibody syndrome, paraneoplastic chorea, and anti-N-methyl-D-aspartate receptor encephalitis.

    Main Methods:

    • Literature review of autoimmune causes of chorea.
    • Synthesis of epidemiological data.
    • Analysis of clinical and laboratory findings.
    • Review of pathogenetic mechanisms.
    • Summary of current management strategies.

    Main Results:

    • Autoimmune disorders represent a rare but important category of chorea etiologies.
    • Key conditions discussed include Sydenham's chorea, SLE, primary APS, paraneoplastic chorea, and anti-NMDAR encephalitis.
    • Understanding these conditions is crucial for accurate diagnosis and effective treatment.

    Conclusions:

    • Autoimmune chorea requires specific diagnostic and therapeutic approaches.
    • Further research into the pathogenesis and treatment of autoimmune chorea is warranted.
    • Clinicians should consider autoimmune causes in the differential diagnosis of chorea.