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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
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Long noncoding RNAs in osteoarthritis.

Shi-de Jiang1, Jian Lu2, Zhen-Han Deng3

  • 1Department of Orthopaedics, The Central Hospital of Yongzhou, Yongzhou 425000, China; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha 410008, China.

Joint Bone Spine
|December 7, 2016
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are implicated in osteoarthritis (OA) development. Targeting these molecules shows promise for controlling OA progression and developing new therapeutic strategies.

Keywords:
Cartilage destructionDisease markerJoint painLong noncoding RNAsOsteoarthritis

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease with incompletely understood pathogenesis.
  • Long noncoding RNAs (lncRNAs) are key regulators in inflammatory diseases, with emerging roles in OA.

Purpose of the Study:

  • To review the association between lncRNAs and OA development and progression.
  • To explore the potential of lncRNAs as therapeutic targets for OA treatment.

Main Methods:

  • Literature review focusing on lncRNA expression and function in OA.
  • Analysis of studies investigating therapeutic targeting of lncRNAs in OA models.

Main Results:

  • Certain lncRNAs are upregulated in OA cartilage, contributing to chondrocyte extracellular matrix degradation.
  • Targeting dysregulated lncRNAs demonstrates significant potential in managing OA progression.

Conclusions:

  • lncRNAs play a critical role in OA pathogenesis by affecting cartilage integrity.
  • Targeting lncRNAs represents a promising avenue for future OA treatment strategies, warranting further clinical investigation.