Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study
Bianca Del-Ponte1, Iná S Santos1, Luciana Tovo-Rodrigues1
1Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Insights
Maternal caffeine intake during pregnancy was not linked to attention deficit hyperactivity disorder (ADHD) in children at age 11. This study found no association between caffeine consumption and ADHD development in offspring.
Area of Science:
- Neuroscience
- Epidemiology
- Public Health
Background:
- Limited research exists on caffeine's impact on child neurodevelopment.
- Inconsistent findings complicate understanding of caffeine's long-term effects during pregnancy.
Purpose of the Study:
- To investigate the association between maternal caffeine consumption during pregnancy and attention deficit hyperactivity disorder (ADHD) in children at age 11.
- To address the scarcity of consistent evidence in this research area.
Main Methods:
- A cohort study included all children born in Pelotas, Brazil, in 2004.
- Maternal caffeine intake (coffee, yerba mate) was recorded at birth.
- Childhood ADHD was assessed at age 11 using the Development and Well-Being Assessment (DAWBA) questionnaire.
Main Results:
- The study analyzed 3485 children; ADHD prevalence was 4.1%.
- Maternal caffeine consumption was prevalent throughout pregnancy (88.7% overall).
- No significant association was found between maternal caffeine intake and ADHD at age 11 in crude or adjusted analyses.
Conclusions:
- This study found no evidence linking maternal caffeine consumption during pregnancy to ADHD in offspring at age 11.
- Further research may be needed to fully elucidate potential subtle effects or specific exposure windows.
Objective:
Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years.
Methodology:
All children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study. The mothers were interviewed at birth to obtain information on coffee and yerba mate consumption during pregnancy, among other matters. At the age of 11 years, presence of ADHD was evaluated using the Development and Well-Being Assessment (DAWBA) questionnaire, applied to the mothers. The prevalence of ADHD was calculated, with 95% CIs. The association between caffeine consumption and ADHD was tested by means of logistic regression.
Results:
3485 children were included in the analyses. The prevalence of ADHD was 4.1% (95% CI 3.4% to 4.7%): 5.8% (95% CI 4.7% to 6.9%) among boys and 2.3% (95% CI 1.5% to 3.0%) among girls. The prevalence of caffeine consumption during the entire pregnancy and in the first, second and third trimesters was 88.7% (87.7% to 89.7%), 86.5% (85.4% to 87.5%), 83.0% (81.8% to 84.2%) and 92.3% (91.4% to 93.1%), respectively. Caffeine consumption during the entire pregnancy and the first, second and third trimesters were not associated with ADHD in the crude or adjusted analysis.
Conclusions:
The present study did not show any association between maternal caffeine consumption during pregnancy and ADHD at the age of 11 years.
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