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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
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Nonalcoholic fatty liver disease - A multisystem disease?
Ivana Mikolasevic1, Sandra Milic1, Tamara Turk Wensveen1
1Ivana Mikolasevic, Sandra Milic, Davor Stimac, Department of Gastroenterology, UHC Rijeka, 51000 Rijeka, Croatia.
World Journal of Gastroenterology
|December 7, 2016
Summary
Non-alcoholic fatty liver disease (NAFLD) is a serious complication of metabolic syndrome (MetS) that can lead to severe liver damage. NAFLD also contributes to other chronic diseases, highlighting the need for early detection and treatment.
Area of Science:
- Hepatology
- Metabolic Diseases
- Cardiovascular Health
Background:
- Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity of overweight and metabolic syndrome (MetS).
- NAFLD can progress to severe liver conditions like fibrosis, cirrhosis, and liver cancer.
- Obesity's rise has made NAFLD the leading cause of chronic liver disease globally.
Purpose of the Study:
- To highlight the systemic impact of NAFLD beyond the liver.
- To emphasize NAFLD's role in the pathophysiology of other chronic diseases.
- To advocate for improved detection and management of NAFLD in patients with MetS.
Main Methods:
- Review of current scientific literature on NAFLD and its systemic effects.
- Analysis of the relationship between NAFLD, MetS, and associated chronic diseases.
- Discussion of emerging non-invasive screening methods for NAFLD.
Main Results:
- NAFLD is linked to increased risk and worsening of cardiovascular disease (CVD), type 2 diabetes (T2DM), and chronic kidney disease (CKD).
- Shared pathophysiological processes like insulin resistance, inflammation, and dyslipidemia underlie NAFLD and associated conditions.
- NAFLD actively exacerbates the progression of CVD, T2DM, and CKD.
Conclusions:
- NAFLD is a significant contributor to multiple chronic diseases associated with MetS.
- Early detection and treatment of NAFLD are crucial for managing associated health risks.
- Healthcare providers should consider NAFLD screening in patients with MetS, utilizing available non-invasive methods.
Keywords:
Cardiovascular diseaseChronic kidney diseaseDiabetes mellitus type 2Metabolic syndromeMultisystem diseaseNonalcoholic fatty liver diseaseMore Related Videos
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