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Adaptive Radiotherapy for an Uncommon Chloroma
Soufya Majdoul1, Laurianne Colson-Durand1, Nu Hanh To1
1Department of Radiation Oncology and Henri Mondor Breast Center, INSERM U955 E07, and University of Paris-Est Créteil (UPEC), Créteil, France.
Case Reports in Oncology
|December 7, 2016
Summary
Granulocytic sarcomas (myeloid sarcomas) are radiosensitive tumors. Adaptive radiotherapy with mid-dose re-evaluation is recommended due to significant tumor reduction during treatment.
Area of Science:
- Oncology
- Radiotherapy
Background:
- Granulocytic sarcomas, also known as myeloid sarcomas or chloromas, are rare extramedullary tumors composed of immature myeloid cells.
- These neoplasms are recognized for their sensitivity to radiation therapy.
Observation:
- The optimal radiation dose and fractionation for granulocytic sarcomas are not standardized.
- Significant tumor volume reduction is typically observed during the course of radiation therapy.
Findings:
- The substantial tumor shrinkage necessitates potential adjustments to the radiation plan.
- An intermediate radiotherapy plan evaluation for adaptive treatment is highly beneficial.
Implications:
- Implementing adaptive radiotherapy allows for precise target volume adjustments, optimizing treatment efficacy.
- A second treatment plan at mid-dose is strongly advised to accommodate tumor regression and improve outcomes for patients with myeloid sarcomas.
