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Mechanisms of Infectivity and Evasion Derived from Microvesicles Cargo Produced by Trypanosoma cruzi

Bruna C Borges1, Isadora A Uehara2, Laysa O S Dias2

  • 1Laboratório de Osteoimunologia e Imunologia dos Tumores, Instituto de Ciências Biomédicas, Universidade Federal de UberlândiaUberlândia, Brazil; Laboratório de Tripanossomatídeos, Instituto de Ciências Biomédicas, Universidade Federal de UberlândiaUberlândia, Brazil.

Frontiers in Cellular and Infection Microbiology
|December 7, 2016
PubMed

Insights

Trypanosoma cruzi releases microvesicles containing molecules that help it evade the host immune system. Understanding these parasite-secreted vesicles offers new therapeutic strategies for Chagas disease.

Area of Science:

  • Parasitology
  • Cell Biology
  • Immunology

Background:

  • Intracellular protozoan infections, like Chagas disease caused by Trypanosoma cruzi, involve complex host-parasite interactions.
  • Parasite evasion of the host immune system is crucial for establishing chronic infections.
  • Microvesicles and exosomes are secreted vesicles involved in intercellular communication.

Purpose of the Study:

  • To review the release of microvesicles by Trypanosoma cruzi.
  • To discuss the molecular composition of these vesicles.
  • To explore their role in host-parasite interactions and immune evasion.

Main Methods:

  • Literature review on microvesicle release by Trypanosoma cruzi.
  • Analysis of molecular content within T. cruzi-derived vesicles.
  • Discussion of the functional implications in host-parasite interactions.

Main Results:

  • Trypanosoma cruzi releases microvesicles containing various molecules.
  • These molecules mediate parasite-host cell interactions.
  • The vesicles contribute to the parasite's immune evasion mechanisms.

Conclusions:

  • T. cruzi microvesicles play a significant role in the parasite's biology and pathogenesis.
  • These findings impact the understanding of Chagas disease.
  • T. cruzi vesicles represent potential targets for novel therapeutic strategies.
Keywords:
Trypanosoma cruzicell evasioncell invasionexosomesmicrovesicles

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