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Proximal Occlusion of Medium-Sized Vessels with the Penumbra Occlusion Device: A Study of Safety and Efficacy
E Jambon1, F Petitpierre1, V Brizzi2
1Department of Radiology, Pellegrin Hospital, Place Amélie Raba Léon, 33076, Bordeaux, France.
Insights
The Penumbra Occlusion Device (POD) offers a safe and effective method for proximal embolization of medium-sized vessels. This study found no device migration and a low complication rate in various clinical settings.
Area of Science:
- Interventional Radiology
- Vascular Surgery
- Medical Devices
Background:
- Proximal embolization is crucial for treating various vascular conditions.
- Medium-sized vessels (4-8 mm) present unique challenges for embolization.
- The Penumbra Occlusion Device (POD) is a novel device for vessel occlusion.
Purpose of the Study:
- To evaluate the safety and efficacy of the Penumbra Occlusion Device (POD) for hybrid proximal coiling.
- To assess POD performance in medium-sized vessels (4-8 mm).
- To investigate POD utility across diverse clinical scenarios.
Main Methods:
- Retrospective analysis of 37 embolizations in 36 patients using PODs.
- Procedures performed between October 2014 and February 2016.
- Vessel occlusion achieved via fluoroscopic guidance with a microcatheter; follow-up via angiography and clinical/imaging assessment.
Main Results:
- POD used alone in 51.4% of cases, as a coil constrainer in 32.4%, and with additional devices in 16.2%.
- Mean follow-up of 3.2 months showed no POD migration.
- A complication rate of 5.4% was observed (post-embolic syndrome, splenic infarction/abscess).
Conclusions:
- The POD system facilitates safe and effective proximal embolization of medium-sized vessels.
- The device demonstrates versatility in various clinical applications.
- POD offers a reliable option for achieving vessel occlusion.
Purpose:
To retrospectively investigate the safety and efficacy of hybrid proximal coiling of various medium-sized vessels (4 to 8 mm) using the Penumbra Occlusion Device (POD).
Materials And Methods:
From October 2014 to February 2016, 37 proximal embolizations were performed with PODs in 36 patients (mean age: 50.8, range: 10-86; 29 male, 7 female). Vessel occlusions were achieved under fluoroscopic guidance using a 2.7 French microcatheter. Among the 36 vessels targeted, 16 were splenic arteries, 11 renal arteries, 4 mesenteric arteries, 3 arteriovenous fistulae, 1 iliac artery, and 1 gonadal vein. Intermittent follow-up angiography was performed to assess the flow for final occlusion. Outcomes and complications were assessed by clinical and/or imaging follow-up.
Results:
To produce proximal occlusion of the intended vessels, the POD was used alone in 19 embolizations (51.4 %). In 12 procedures (32.4 %), POD was used as a coil constrainer to secure the coil construct. In 6 procedures (16.2 %), additional embolic devices were used to achieve vessel occlusion after initial POD deployment. After a mean follow-up of 3.2 months, no POD migration was observed but two complications occurred (5.4 %): one post embolic syndrome and one extensive infarction with splenic abscess.
Conclusion:
The POD system allows safe and effective proximal embolization of medium-sized vessels in a variety of clinical settings.
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