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Impact of exercise on fecal and cecal metabolome over aging: a longitudinal study in rats

Olga Deda1, Helen Gika2, Theodoros Panagoulis1

  • 1School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Bioanalysis
|December 7, 2016
PubMed
Abstract

Keywords:
GC–MSLC–MSagingcecal samplesexercisefecal samplesmetabolomicsrats

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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