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Updated: Sep 6, 2026
In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
Published on: February 21, 2018
A new hypothesis on the plurifactorial etiology of Meniere's disease
Abstract:
Meniere's disease is characterized by an extremely long trend: this fact, as in other diseases of very wide chronicity, permits one to formulate a special type of hypothesis regarding the aetiology and the pathogenesis of the disease; it is comprised of many individual factors, of differing chronology and which are connected to each other with successive causality. This hypothesis was founded on a large body of data concerning the multiple histopathological effects on the inner ear of an initially inflammatory disease of the middle ear.
Insights
Meniere
Area of Science:
- Otolaryngology and Neurotology
- Chronic disease pathogenesis
Background:
- Meniere's disease presents a prolonged, chronic course.
- This chronicity allows for the development of unique etiological and pathogenetic hypotheses.
- These hypotheses consider multifactorial influences with sequential causality.
Purpose of the Study:
- To propose a novel hypothesis for Meniere's disease etiology and pathogenesis.
- To investigate the role of chronic inflammatory processes in the inner ear.
Main Methods:
- Analysis of extensive data on histopathological changes in the inner ear.
- Correlation of these changes with preceding inflammatory conditions of the middle ear.
Main Results:
- Identified a pattern of multiple histopathological effects within the inner ear.
- These effects are linked to prior inflammatory middle ear diseases.
Conclusions:
- Meniere's disease pathogenesis may involve a cascade initiated by middle ear inflammation.
- A multifactorial, chronologically dependent hypothesis for Meniere's disease is supported by histopathological evidence.
