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Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and
S H Sindrup1, B Ejlertsen, A Frøland
1Department of Internal Medicine, Fredericia Hospital, Denmark.
European Journal of Clinical Pharmacology
|January 1, 1989
Abstract:
The effect of imipramine on symptomatic peripheral diabetic neuropathy in 9 patients was examined in a double-blind cross-over study against placebo. The dose of imipramine was adjusted to yield optimal plasma levels of imipramine plus desipramine of 300-750 nM. Imipramine had a clear beneificial effect on the symptoms of the neuropathy, whereas no changes in a range of neurophysiological measurement was detected. Despite some adverse effects, especially of an anticholinergic nature, the patients generally preferred imipramine to placebo.