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Related Experiment Video

Updated: Mar 10, 2026

Measuring Oxidative Stress Resistance of Caenorhabditis elegans in 96-well Microtiter Plates
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Chemically induced oxidative stress affects ASH neuronal function and behavior in C. elegans.

Eleni Gourgou1,2, Nikos Chronis1,3

  • 1Department of Mechanical Engineering, University of Michigan, 2350 Hayward Str., Ann Arbor, MI, 48109, USA.

Scientific Reports
|December 7, 2016
PubMed
Summary

Oxidative stress enhances the function of the ASH neuron in C. elegans, leading to improved avoidance behaviors. This suggests a hormetic effect of paraquat-induced oxidative stress on neuronal function.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Genetics

Background:

  • The impact of oxidative stress on individual neuron function in living organisms is not well understood.
  • Investigating neuronal responses to oxidative stress is crucial for understanding neurological health and disease.

Purpose of the Study:

  • To investigate the effects of paraquat-induced oxidative stress on the function of the ASH polymodal neuron in C. elegans.
  • To determine if oxidative stress influences ASH-dependent behaviors and locomotion.

Main Methods:

  • Utilized calcium imaging to quantify ASH neuron activation in response to stimuli.
  • Administered paraquat to induce oxidative stress in wild-type C. elegans.
  • Conducted octanol and osmotic avoidance tests to assess ASH-dependent behaviors.
  • Measured locomotion parameters including velocity and bending amplitude.

Main Results:

  • Paraquat-induced oxidative stress led to increased depolarization and faster response times in ASH neurons.
  • Worms exposed to paraquat exhibited enhanced avoidance behaviors.
  • Vitamin C partially mitigated the effects of oxidative stress on ASH neuron function.
  • Locomotion velocity decreased in older adult worms, while bending amplitude remained unaffected.

Conclusions:

  • Mild oxidative stress, induced by paraquat, may exert a hormetic effect on neuronal function.
  • Enhanced ASH neuron activity correlates with improved ASH-mediated avoidance behaviors.
  • Oxidative stress can have differential impacts on various neuronal functions and behaviors within an organism.