Related Experiment Video

Updated: Mar 10, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Paediatric renal tumours: perspectives from the SIOP-RTSG

    Nature Reviews. Urology
    |December 7, 2016
    PubMed

    Insights

    Wilms tumour survival rates exceed 90% in children, yet 20% relapse and 25% face severe late effects. The SIOP Renal Tumour Study Group aims to improve outcomes and reduce treatment toxicity for all children.

    Area of Science:

    • Pediatric oncology
    • Cancer research
    • Clinical trials

    Background:

    • Wilms tumour exhibits high overall survival rates (>90%) in pediatric patients.
    • Current treatment protocols have reduced therapy intensity for many children.
    • Significant challenges remain, including a 20% relapse rate and 25% incidence of severe late effects in survivors.

    Purpose of the Study:

    • To enhance treatment outcomes for children diagnosed with Wilms tumour.
    • To minimize both acute and long-term treatment-related toxicities.
    • To address the unmet needs in Wilms tumour management, focusing on reducing relapse and late effects.

    Main Methods:

    • The study is conducted under the auspices of the SIOP Renal Tumour Study Group (SIOP-RTSG).
    • Focuses on optimizing current therapeutic strategies and exploring novel approaches.
    • Involves a multidisciplinary approach to patient care and treatment evaluation.

    Main Results:

    • While overall survival is high, specific patient subgroups experience treatment failure.
    • A substantial proportion of survivors endure severe long-term health issues.
    • The study seeks to identify factors contributing to relapse and late effects.

    Conclusions:

    • Despite high survival rates, further improvements in Wilms tumour treatment are necessary.
    • Reducing treatment-related morbidity is a critical goal alongside survival.
    • The SIOP-RTSG is dedicated to advancing the care of children with Wilms tumour through research and protocol development.

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