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Hyperuricemia as a risk factor for cardiovascular disease: clinical review

Álvaro Gudiño Gomezjurado1

  • 1Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito, Ecuador. Address: Calle Teodoro Sampaio 10-20, Pinheiros, São Paulo, Brasil.

Medwave
|December 7, 2016
PubMed

Insights

Hyperuricemia, a condition of high uric acid levels, is debated as an independent cardiovascular disease risk factor. This review examines its link to hypertension, coronary heart disease, heart failure, and atrial fibrillation.

Area of Science:

  • Cardiology
  • Nephrology
  • Internal Medicine

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of death.
  • Established CVD risk factors include hypertension, dyslipidemia, and diabetes.
  • The role of hyperuricemia as an independent CVD risk factor remains controversial.

Purpose of the Study:

  • To critically evaluate the association between hyperuricemia and major cardiovascular diseases.
  • To clarify the independent contribution of hyperuricemia to CVD development.

Main Methods:

  • A comprehensive literature review was conducted.
  • Relevant published studies assessing hyperuricemia and CVD were analyzed.
  • Specific focus on hypertension, coronary heart disease, heart failure, and atrial fibrillation.

Main Results:

  • Evidence suggests a correlation between hyperuricemia and increased risk of hypertension.
  • Hyperuricemia is associated with higher incidence and severity of coronary heart disease.
  • Links between hyperuricemia and heart failure as well as atrial fibrillation were observed.

Conclusions:

  • Hyperuricemia may represent an independent risk factor for several cardiovascular diseases.
  • Further research is warranted to elucidate the causal mechanisms.
  • Managing hyperuricemia could be a potential strategy for CVD prevention.

Keywords:
atrial fibrillationcardiovascular diseasecoronary diseaseheart failurehypertensionhyperuricemia

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