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Lung regeneration: steps toward clinical implementation and use.

Elizabeth A Calle¹, Katherine L Leiby, MichaSam B Raredon

¹aYale School of Medicine bDepartment of Biomedical Engineering cDepartment of Anesthesiology, Yale University, New Haven, Connecticut, USA.

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|December 7, 2016

Summary

Whole lung tissue engineering is advancing rapidly, moving towards large animal studies and clinical relevance. Current research refines components and uses stem cells for lung regeneration, with a focus on functional evaluation.

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Methods for the Study of Regeneration in Stentor

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Pulmonology

Background:

Whole lung tissue engineering is an emerging field.
Significant advancements have been made, progressing beyond rodent models.
The technology is nearing clinical applicability and large animal studies.

Purpose of the Study:

To review the current state of whole lung tissue engineering.
To highlight advancements in fundamental components and cell-based approaches.
To emphasize the importance of functional evaluation for clinical translation.

Main Methods:

Refinement of foundational elements for engineered lungs.
Directed differentiation of induced pluripotent stem cells and lung progenitor cells.
In vitro and in vivo functional assessments of engineered lung constructs.

Main Results:

Progress in optimizing the core components of whole lung engineering.
Increased focus on utilizing stem and progenitor cells for lung regeneration.
Development of robust methods for functional evaluation in preclinical settings.

Conclusions:

The ultimate aim is to develop a clinically viable engineered lung product.
Current tools advance understanding of lung biology and stem/progenitor cell regenerative potential.
The field is poised for scale-up to large animal models and potential clinical application.