Related Experiment Video

Updated: Mar 10, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.4K

Microbiology and Antimicrobial Challenges of Prosthetic Joint Infection

Douglas R Osmon1

  • 1From the Department of Infectious Diseases, Mayo Clinic, Rochester, MN.

The Journal of the American Academy of Orthopaedic Surgeons
|December 7, 2016
PubMed

Insights

Prosthetic joint infection (PJI) following knee replacement requires improved diagnosis and treatment strategies. Future research should focus on PJI microbiology, antimicrobial resistance, and enhanced antimicrobial therapies for better patient outcomes.

Area of Science:

  • Orthopedic surgery
  • Infectious diseases
  • Microbiology

Background:

  • Prosthetic joint infection (PJI) is a severe complication of total knee arthroplasty.
  • Effective diagnosis and treatment of PJI are crucial for patient recovery and implant survival.

Purpose of the Study:

  • To outline future research directions for prosthetic joint infection (PJI).
  • To address critical aspects of PJI microbiology, antimicrobial resistance, and treatment strategies.

Main Methods:

  • This review summarizes expert opinions presented at a multidisciplinary research conference.
  • Focuses on a session dedicated to periprosthetic joint infections.

Main Results:

  • Highlights the need for advancements in understanding PJI microbiology.
  • Emphasizes the importance of developing improved systemic and local antimicrobial therapies.
  • Identifies antimicrobial resistance as a key challenge in PJI management.

Conclusions:

  • Further research into PJI microbiology and antimicrobial resistance is essential.
  • Optimizing antimicrobial treatment strategies, both systemic and local, is critical for managing PJI.
  • Enhanced strategies are needed to combat this devastating complication of knee arthroplasty.

More Related Videos

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.6K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.9K

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.2K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.3K
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
42.5K
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
296
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
648
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.6K