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Updated: Mar 10, 2026
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
475
Strategies to use microRNAs as therapeutic targets
Erica Gentilin1, Ettore Degli Uberti1, Maria Chiara Zatelli1
1Section of Endocrinology and Internal Medicine, Dept. of Medical Sciences, University of Ferrara, Italy.
Best Practice & Research. Clinical Endocrinology & Metabolism
|December 8, 2016
Summary
MicroRNAs (miRNAs) regulate gene expression and their dysregulation is linked to pituitary tumors. This review details altered miRNAs in pituitary tumors and their functions, exploring therapeutic and biomarker potential.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- MicroRNAs (miRNAs) are key post-transcriptional gene regulators.
- Aberrant miRNA expression is implicated in various diseases, including pituitary adenomas.
- Pituitary tumors exhibit altered miRNA profiles affecting physiological functions.
Purpose of the Study:
- To review current knowledge on deregulated miRNAs in pituitary tumors.
- To analyze miRNA functions within different pituitary tumor subtypes.
- To discuss the potential of miRNAs as therapeutics and biomarkers for pituitary neoplasms.
Main Methods:
- Literature review of studies on miRNA deregulation in pituitary tumors.
- Classification of pituitary tumors by histotype, dimension, and aggressiveness.
- Analysis of functional roles of identified miRNAs.
Main Results:
- Specific miRNAs are consistently deregulated across various pituitary tumor classes.
- Altered miRNAs influence key cellular pathways relevant to pituitary tumorigenesis.
- Evidence suggests miRNAs can serve as diagnostic and prognostic markers.
Conclusions:
- miRNA dysregulation is a significant factor in pituitary tumor development and progression.
- Targeting specific miRNAs may offer novel therapeutic strategies.
- miRNAs hold promise as sensitive biomarkers for pituitary adenoma detection and management.
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