[Enzymatic synthesis and immunochemical characterization of conjugated morphine-protein antigens]

Conjugates morphine-protein which are formed in the systems of cytochrome P-450 and horse-radish peroxidase can induce in rabbits synthesis of the specific antibodies to morphine. In the blood of animals immunized with the above mentioned conjugates there are antimorphine-antibodies being constituents on immunochemical complexes with endogenous ligands. Administration to rabbits of the conjugated antigen morphine-microsomes of the rabbit liver causes the development of the reaction of hypersensitivity of delayed type to morphine.