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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Layer-by-layer nanoparticle platform for cancer active targeting.

Min Sung Suh1, Jie Shen1, Liisa T Kuhn2

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.

International Journal of Pharmaceutics
|December 8, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces novel core-shell nanoparticles for targeted cancer therapy. These biocompatible nanoparticles enhance drug efficacy by delivering cisplatin specifically to lung cancer cells, improving treatment outcomes.

Keywords:
CD44NanoparticlesPlatformTargeted cancer therapypH-sensitive

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Nanoparticles are explored for targeted cancer drug delivery to enhance efficacy and reduce side effects.
  • Developing biocompatible carriers with specific targeting is crucial for effective cancer therapy.

Purpose of the Study:

  • To develop and characterize a novel core-shell nanoparticle platform for targeted cancer drug delivery.
  • To evaluate the efficacy and drug release characteristics of cisplatin-loaded nanoparticles.

Main Methods:

  • Core-shell nanoparticles were synthesized using calcium phosphate (core) and hyaluronic acid/chitosan (shell).
  • Cisplatin was incorporated, and nanoparticles were optimized for stability and low protein binding.
  • Targeted delivery and efficacy were assessed in human lung cancer cells overexpressing CD44 receptors.

Main Results:

  • The nanoparticles demonstrated high serum stability and low protein binding.
  • Targeted delivery to CD44-overexpressing lung cancer cells was confirmed.
  • An 8-fold increase in drug efficacy (IC50) was observed compared to free cisplatin.
  • pH-sensitive core destabilization enabled controlled drug release in acidic conditions.

Conclusions:

  • The developed nanoparticle platform offers a simple approach for targeted, biocompatible drug delivery in cancer therapy.
  • This technology shows promise for improving cancer treatment by enhancing drug efficacy and enabling controlled release.