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Global epidemiology and burden of HCV infection and HCV-related disease

Aaron P Thrift1,2, Hashem B El-Serag1,3, Fasiha Kanwal1,3

  • 1Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Suite 10C, Houston, Texas, USA.

Nature Reviews. Gastroenterology & Hepatology
|December 8, 2016
PubMed

Insights

Chronic Hepatitis C Virus (HCV) infection impacts over 184 million globally, causing liver and other diseases. Understanding HCV

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Epidemiology

Background:

  • Chronic Hepatitis C Virus (HCV) infection is a significant global health issue affecting over 184 million individuals.
  • HCV is linked to numerous hepatic and extrahepatic disorders, including various malignancies.
  • The disease burden is shaped by incidence, prevalence, and the infection's natural history.

Purpose of the Study:

  • To review the global epidemiology and burden of HCV infection and its complications.
  • To discuss the natural history and clinical course of both chronic and cured HCV infection.
  • To inform strategies for detection, prognostication, and treatment in light of new antiviral therapies.

Main Methods:

  • This is a review article.
  • It synthesizes existing data on HCV epidemiology and natural history.
  • Focuses on factors influencing HCV burden and disease progression.

Main Results:

  • HCV infection presents a substantial global health burden with significant variations across populations and regions.
  • Demographic, virological, clinical, and lifestyle factors influence the natural history of HCV.
  • New antiviral treatments necessitate understanding disease burden changes in both chronic and cured patients.

Conclusions:

  • Effective HCV management requires understanding the determinants of its global burden.
  • Further research is needed on the long-term outcomes and disease burden in patients cured of HCV.
  • This review provides a comprehensive overview to guide future public health interventions and clinical management.

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