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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Cardiac Resynchronization Therapy prevents progression of renal failure in heart failure patients

Vinodh Jeevanantham1, Mohit Turagam2, David Shanberg1

  • 1University of Kansas Medical Center, Kansas City, KS, USA.

Indian Pacing and Electrophysiology Journal
|December 8, 2016
PubMed

Insights

Cardiac resynchronization therapy (CRT) stabilized renal function in heart failure patients, particularly improving advanced chronic kidney disease (CKD). Stable or improved kidney function after CRT predicted lower mortality.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Cardiac resynchronization therapy (CRT) is used for heart failure, but its long-term effects on renal function are not fully understood.
  • Assessing CRT's impact on kidney function is crucial for managing heart failure patients with co-existing renal disease.

Purpose of the Study:

  • To evaluate the long-term effects of CRT on renal function in heart failure patients.
  • To determine the association between changes in renal function post-CRT and patient mortality.

Main Methods:

  • Retrospective review of 588 patients who underwent CRT implantation between 2000-2009.
  • Renal function (GFR) and cardiac function (LVEF) assessed short-term (≤6 months) and long-term (>6 months) post-CRT.
  • Chronic kidney disease (CKD) staging based on KDOQI guidelines.

Main Results:

  • No significant overall decline in Glomerular Filtration Rate (GFR) was observed post-CRT.
  • Significant renal function improvement noted in patients with advanced CKD (stage 4 and 5).
  • Stable or improved GFR independently predicted lower mortality.

Conclusions:

  • CRT is associated with renal function stabilization in severe left ventricular dysfunction.
  • CRT can improve renal function in patients with stage 4 and 5 CKD.
  • Enhanced renal function post-CRT correlates with reduced mortality risk.
Abstract

Keywords:
Cardiac Resynchronization TherapyChronic kidney diseaseCongestive heart failureGlomerular filtration rateImplantable cardioverter defibrillator

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