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Related Experiment Video

Updated: Mar 10, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

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Published on: September 1, 2014

P-wave dispersion: an update.

Andrés Ricardo Pérez-Riera¹, Luiz Carlos de Abreu², Raimundo Barbosa-Barros³

¹Design of Studies and Scientific Writing Laboratory in the ABC Medicine Faculty, Santo André, São Paulo, Brazil.

Indian Pacing and Electrophysiology Journal

|December 8, 2016

Summary

P-wave dispersion (PWD) is an ECG marker indicating atrial remodeling and a predictor for atrial fibrillation (AF). Increased PWD signifies conduction delays and fibrosis, contributing to atrial arrhythmias.

Keywords:

Interatrial block Intraatrial block P-wave dispersion P-wave duration Paroxysmal atrial fibrillation

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Area of Science:

Cardiology
Electrophysiology

Background:

P-wave dispersion (PWD) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and a predictor for atrial fibrillation (AF).
PWD quantifies the variability in P-wave duration across 12 ECG leads, reflecting intra- and interatrial conduction abnormalities.

Approach:

This abstract discusses the electrophysiological underpinnings of increased PWD.
It highlights the association between PWD, atrial fibrosis, and genetic polymorphisms like IL-6 -634C/G.

Key Points:

Increased PWD indicates prolonged conduction times and disorganized atrial activation.
Atrial fibrosis, interstitial fibroblast activation, and collagen deposition contribute to PWD.
Interleukin-6 (IL-6) mediated inflammatory effects are implicated in patients with specific IL-6 genotypes.

Conclusions:

PWD is a valuable ECG marker for assessing atrial remodeling and predicting AF risk.
Understanding the mechanisms behind PWD provides insights into atrial arrhythmogenesis.