Related Experiment Video
Updated: Mar 10, 2026
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
A Novel Adjuvant-Solution Layer Strategy for Improving the Efficacy of Cryosurgery
K K Ramajayam1, A Kumar2, S K Sarangi2
1Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha-769008, India.
Background:
During cryosurgery, studies reported earlier suggest increased destruction inside the tumour due to adjuvants or the prevention of damage to neighbouring healthy tissue through different methods.
Objective:
This study advocates a novel strategy that increases the freezing inside agarose gel phantoms by addition of glycine and limits the freezing to the desired location using a perfluorohexane layer during cryosurgery.
Materials And Methods:
Cryosurgery of glycine containing gels is carried out with and without perfluorohexane layer and the thermal history is measured using K-type thermocouples connected to a data acquisition system.
Results:
The presence of glycine causes increased freezing during cryosurgery with an ice ball depth of 16 mm, while with a perfluorohexane layer at this gel interface, this depth is 13 mm, indicating the ability of this layer to limit freezing.
Conclusion:
It can be concluded that glycine addition results in substantial temperature decrease and perfluorohexane layer insulates the glycine gel effectively during cryosurgical cooling.
