Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

11.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
11.7K
Selectins01:25

Selectins

4.6K
Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
4.6K
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

5.0K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
5.0K
Antimicrobial Proteins01:23

Antimicrobial Proteins

15.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
15.1K
Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

3.9K
Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digital quantum magnetism on a trapped-ion quantum computer.

Nature·2026
Same author

When Incidental Becomes Instrumental: A Thyroid Metastasis Unmasked.

Practical radiation oncology·2025
Same author

Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

A Bayesian approach to time-domain photonic Doppler velocimetry analysis.

The Review of scientific instruments·2025
Same author

SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON.

Drug testing and analysis·2025
Same author

A case of cutaneous melanocytoma in a 2-year-old Friesian bull.

New Zealand veterinary journal·2025
Same journal

The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management.

Clinical and experimental immunology·2026
Same journal

PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

Clinical and experimental immunology·2026
Same journal

Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

Clinical and experimental immunology·2026
Same journal

Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

Clinical and experimental immunology·2026
Same journal

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
Same journal

Clinical, genetic, and functional characterization of novel NFKB1 variants in Chinese patients with primary immunodeficiency.

Clinical and experimental immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 10, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

14.4K

Lectin complement pathway proteins in healthy individuals.

A Troldborg1,2, A Hansen3, S W K Hansen4

  • 1Department of Rheumatology, Aarhus University, Aarhus, Denmark.

Clinical and Experimental Immunology
|December 8, 2016
PubMed
Summary
This summary is machine-generated.

Understanding normal lectin pathway protein levels in serum and plasma is crucial. This study details concentrations, revealing significant variations based on collection method, diurnal rhythm, and gender, but not age.

Keywords:
complement systemdiurnal variationinnate immunitylectin pathway

More Related Videos

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Related Experiment Videos

Last Updated: Mar 10, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

14.4K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Area of Science:

  • Immunology
  • Complement System Biology

Background:

  • The lectin pathway of complement activation is a key immune system component.
  • Understanding normal protein concentrations is essential for identifying abnormalities and developing biomarkers.

Purpose of the Study:

  • To establish reference ranges for 11 lectin pathway proteins in serum and plasma.
  • To investigate potential gender, age, and diurnal variations in these protein concentrations.

Main Methods:

  • Quantified 11 lectin pathway proteins (MBL, H-ficolin, L-ficolin, M-ficolin, collectin-K1, collectin-L1, MASP-2, MASP-3, MAp44, MAp19, and developed assay for MASP-1) in 300 Danish blood donors.
  • Analyzed samples collected in serum and EDTA plasma.

Main Results:

  • Significant differences in protein concentrations were observed between serum and plasma for most analytes, except MBL and MASP-3.
  • H-ficolin, M-ficolin, and MAp19 showed notable diurnal variations, with H-ficolin levels decreasing significantly from morning to night.
  • Gender influenced the concentrations of most proteins, while age did not show a significant impact.

Conclusions:

  • The choice of sample type (serum vs. plasma) and consideration of diurnal and gender variations are critical for accurate interpretation of lectin pathway protein levels in cohort studies.
  • These findings highlight the need for standardized protocols and careful study design to ensure the clinical relevance of biomarker discovery.