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Updated: Mar 10, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
'Low grade glioma': an update for radiologists
Jennifer Larsen1, Steve B Wharton2,3, Fiona McKevitt4
11 Department of Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Abstract:
With the recent publication of a new World Health Organization brain tumour classification that reflects increased understanding of glioma tumour genetics, there is a need for radiologists to understand the changes and their implications for patient management. There has also been an increasing trend for adopting earlier, more aggressive surgical approaches to low-grade glioma (LGG) treatment. We will summarize these changes, give some context to the increased role of tumour genetics and discuss the associated implications of their adoption for radiologists. We will discuss the earlier and more radical surgical resection of LGG and what it means for patients undergoing imaging.

