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[Experiences with transcervical chorionic villi biopsy in 274 studies]
G Karkut1, R Becker, K Starzinski
1Freie Universität Berlin, Klinikum Steglitz, Gynäkologische Klinik und Poliklinik, Berlin.
Geburtshilfe Und Frauenheilkunde
|August 1, 1989
Summary
Chorionic villi sampling (CVS) provided diagnostically usable results in most pregnancies, identifying chromosomal aberrations and translocations. While miscarriage occurred in 5.8% of CVS patients, many pregnancies with abnormal results were successfully managed.
Area of Science:
- Prenatal Diagnostics
- Medical Genetics
- Obstetrics
Context:
- The study was conducted at Klinikum Steglitz Medical Center, Free University of Berlin, between 1985-1987.
- 274 transcervical chorionic villi biopsy samples were analyzed.
- Data from 264 pregnancies (96.3% of total) were available for outcome assessment.
Purpose:
- To evaluate the diagnostic yield and safety of transcervical chorionic villi sampling (CVS).
- To assess the rate of chromosomal aberrations and pregnancy outcomes following CVS.
- To analyze complications associated with the CVS procedure.
Summary:
- 229 cases (83.6%) yielded diagnostically usable results from CVS.
- Abnormal chromosomal results were found in 14 patients, leading to pregnancy termination in 6 cases due to aberrations.
- Miscarriage occurred in 5.8% of CVS patients; other complications included febrile and septic abortions.
Impact:
- CVS is a valuable tool for prenatal diagnosis of chromosomal abnormalities.
- The study highlights the importance of follow-up procedures like amniocentesis for mosaic findings.
- Understanding complication rates is crucial for informed patient counseling and clinical practice.