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Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
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Immunoglobulin therapy.

Sarah Louise Johnston1, Rob Hollingsworth2

  • 1North Bristol NHS Trust, Bristol, UK.

Clinical Medicine (London, England)
|December 9, 2016
PubMed
Summary

Immunoglobulin is a vital but costly blood product. A new demand management program aims to ensure supply for critical treatments and restrict use where evidence is insufficient.

Area of Science:

  • Immunology
  • Hematology
  • Pharmacoeconomics

Background:

  • Immunoglobulin (Ig) is a valuable blood product with diverse clinical applications.
  • Its use is associated with significant cost and potential risks, including blood-borne infections.
  • Historically, immunoglobulin supply has faced limitations and concerns regarding appropriate utilization.

Purpose of the Study:

  • To describe the establishment of a demand management program for immunoglobulin.
  • To outline strategies for optimizing immunoglobulin supply and use.
  • To ensure immunoglobulin is prioritized for patients with clear indications and strong evidence.

Main Methods:

  • Collaboration between the Department of Health and relevant stakeholders.
  • Development of a national demand management program.
Keywords:
Blood productdemand managementimmunoglobulinimmunomodulatoryreplacement

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  • Implementation of guidelines for appropriate immunoglobulin prescribing and recording.

    • Main Results:

    • A structured program is in place to manage immunoglobulin demand.
    • Efforts are focused on securing supply for essential treatments.
    • Strategies aim to limit immunoglobulin use for unproven indications.

    Conclusions:

    • Careful consideration, prescription, and recording of immunoglobulin are essential.
    • The demand management program seeks to balance patient needs with resource availability.
    • Prioritizing immunoglobulin for evidence-based indications is crucial for effective healthcare resource allocation.