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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
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An update on mast cell disorders.

Hannah Cookson1, Clive Grattan2

  • 1St John's Institute of Dermatology, Guys and St Thomas's Hospitals, London, UK hannahscookson@gmail.com.

Clinical Medicine (London, England)
|December 9, 2016
PubMed
Summary
This summary is machine-generated.

Diagnosing mast cell activation disorders requires a structured approach due to varied symptoms. This review outlines diagnostic strategies and treatment options for mast cell activation syndromes.

Keywords:
Activationdisordermast cellmast cell disordersmastocytosistryptase

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Area of Science:

  • Immunology
  • Hematology
  • Allergy and Clinical Immunology

Background:

  • Mast cell activation disorders (MCADs) encompass primary (mastocytosis), secondary (reactive), and idiopathic conditions.
  • Patients present with diverse and complex symptoms, complicating diagnosis.
  • Accurate diagnosis is crucial for effective management of MCADs.

Purpose of the Study:

  • To provide a systematic approach for recognizing and diagnosing patients with suspected abnormal mast cell activation.
  • To discuss current treatment strategies for mast cell activation disorders.

Main Methods:

  • Review of diagnostic criteria and clinical presentations of MCADs.
  • Outline of a step-wise diagnostic algorithm for suspected cases.
  • Categorization of treatment options based on mechanism of action.

Main Results:

  • A logical, step-wise diagnostic approach is recommended for complex MCAD presentations.
  • Treatment strategies include mitigating mast cell mediator effects and mast cell stabilization.
  • Early and accurate diagnosis facilitates appropriate patient management.

Conclusions:

  • A structured diagnostic pathway is essential for identifying mast cell activation disorders.
  • Therapeutic interventions target either mediator effects or mast cell stability.
  • This review aids clinicians in managing patients with suspected MCADs.