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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
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Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction
Giulia Torriani1, Clara Galan-Navarro1, Stefan Kunz2
1Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Abstract:
Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.
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