[Principles of growth of unidirectional combined effects of harmful substances after increase in their quantity]

The experiments on the impact of 4 noxious substances (copper, lead, zinc and cadmium salts) were carried out separately and in all possible combinations on 2 pure lines of cell culture. It was found out that a detrimental combined effect grew more slowly than one could expect proceeding from theoretical assumptions. The technique for calculating the maximum effect of the combination of noxious substances was proposed.