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Published on: April 29, 2014
Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review
John J Bissler1, John C Kingswood2
1FedEx Chair of Excellence, Director, Tuberous Sclerosis Center of Excellence, Director, Division of Nephrology at St. Jude Children's Research Hospital and LeBonheur Children's Hospital, University of Tennessee Health Science Center, Professor of Pediatrics, 51 North Dunlap Street, Memphis, TN 38103, USA.
Abstract:
Renal angiomyolipomata associated with tuberous sclerosis complex are often bilateral, multiple and progressive. They cause significant morbidity and mortality in older children and adults. Surveillance and pre-emptive treatment reduce this risk. Recent research suggests treatment with mammalian target of rapamycin inhibitors is better at preventing bleeding, recurrence, and preserving renal function than percutaneous embolization.
