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Tracking silver delivery to bacteria using turn-on fluorescence.

Miguel N Pinto1, Indranil Chakraborty1, Wiley Schultz-Simonton1

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. pradip@ucsc.edu.

Chemical Communications (Cambridge, England)
|December 9, 2016
PubMed
Summary
This summary is machine-generated.

We developed a new silver complex that lights up when it releases silver, showing its potential for bacterial treatment. This complex is as effective as silver nitrate and can be tracked in bacteria using microscopy.

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Area of Science:

  • Coordination Chemistry
  • Photophysics
  • Antimicrobial Agents

Background:

  • Silver complexes are investigated for their antimicrobial properties.
  • Fluorescent probes offer real-time tracking of therapeutic agents.
  • Developing novel silver-based compounds with enhanced functionalities is crucial.

Purpose of the Study:

  • To synthesize and characterize a novel silver complex, [Ag(qBODIPY)(CF3SO3)] (1).
  • To investigate the fluorescence properties of complex 1 upon silver ion release.
  • To evaluate the antimicrobial efficacy and bacterial targeting of complex 1.

Main Methods:

  • Synthesis and characterization of the silver complex [Ag(qBODIPY)(CF3SO3)] (1).
  • Spectroscopic analysis to determine fluorescence changes upon silver release.
  • Minimum inhibitory concentration (MIC) assays to assess antimicrobial activity.
  • Confocal microscopy for visualizing silver delivery to bacterial cells.

Main Results:

  • The novel silver complex [Ag(qBODIPY)(CF3SO3)] (1) was successfully synthesized.
  • Complex 1 displays a significant increase in fluorescence intensity upon the release of silver ions.
  • The minimum inhibitory concentration of complex 1 is comparable to that of silver nitrate.
  • Confocal microscopy confirmed the successful delivery of silver to bacterial targets.

Conclusions:

  • The developed silver complex shows promising fluorescence-based detection upon silver release.
  • Complex 1 exhibits potent antimicrobial activity, similar to silver nitrate.
  • The study demonstrates the potential of this complex for targeted silver delivery and antimicrobial applications.