Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

9.9K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccine fatigue and influenza vaccination trends across Pre-, Peri-, and Post-COVID-19 periods in the United States using epic's cosmos database.

PloS one·2025
Same author

Depression: Managing Resistance and Partial Response to Treatment.

American family physician·2024
Same author

Smell and Taste Disorders in Primary Care.

American family physician·2023
Same author

Smoking Cessation Interventions.

American family physician·2022
Same author

Unintentional Weight Loss in Older Adults.

American family physician·2021
Same author

Endometrial Biopsy: Tips and Pitfalls.

American family physician·2020

Related Experiment Video

Updated: Mar 10, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

127

Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis.

Heidi L Gaddey1, Angela M Riegel1

  • 1Ehrling Bergquist Family Medicine Residency Program, Offutt Air Force Base, NE, USA.

American Family Physician
|December 9, 2016
PubMed
Summary

Most lymphadenopathy is benign. Evaluation involves history, physical exam, and considering risk factors for malignancy. Further workup, including biopsy, guides diagnosis and treatment for persistent or concerning cases.

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K
Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
07:04

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Published on: September 16, 2018

10.9K

Related Experiment Videos

Last Updated: Mar 10, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

127
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K
Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
07:04

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation

Published on: September 16, 2018

10.9K

Area of Science:

  • Internal Medicine
  • Pathology
  • Oncology

Background:

  • Lymphadenopathy, or swollen lymph nodes, is common and often benign.
  • However, it can signify serious underlying conditions like malignancy, infection, or autoimmune disorders.
  • Accurate diagnosis is crucial for appropriate patient management.

Purpose of the Study:

  • To outline the diagnostic approach to lymphadenopathy.
  • To differentiate between localized and generalized lymphadenopathy.
  • To identify risk factors for malignancy and guide further investigation.

Main Methods:

  • Clinical evaluation including history and physical examination.
  • Classification of lymphadenopathy as localized or generalized.
  • Consideration of patient demographics and specific node characteristics.
  • Diagnostic workup may include blood tests, imaging, and various biopsy techniques (FNA, core, excisional).

Main Results:

  • History and physical exam often suffice for diagnosis.
  • Localized lymphadenopathy requires region-specific evaluation.
  • Generalized lymphadenopathy suggests systemic disease.
  • Risk factors for malignancy include age >40, male sex, white race, supraclavicular location, and systemic symptoms.
  • Specific palpable nodes (supraclavicular, popliteal, iliac, epitrochlear >5mm) are abnormal.

Conclusions:

  • A systematic approach to lymphadenopathy is essential.
  • Biopsy is reserved for cases with unknown etiology or high suspicion of malignancy.
  • Antibiotics for acute cervical lymphadenitis and caution with corticosteroid use are recommended.
  • Timely diagnosis ensures appropriate treatment and management of underlying causes.