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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
The Emergence of the Dose-Response Concept in Biology and Medicine
1School of Public Health & Health Sciences, Environmental Health Sciences, Morrill I-N344, University of Massachusetts, Amherst, MA 01003, USA. edwardc@schoolph.umass.edu.
Abstract:
A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.
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