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Updated: Mar 10, 2026

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Published on: August 23, 2019
Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma
Xinwen Nie1, Fang Yuan1, Peng Chen2
1Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
Aim:
IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC).
Materials & Methods:
IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method.
Results:
The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05).
Conclusion:
These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
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