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Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Jun Lu1,2, Xuhong Hou1, Hong Tu3

  • 1Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Journal of Diabetes Investigation
|December 9, 2016
PubMed

Insights

Chronic hepatitis B virus infection (CHB) is more common in individuals with type 2 diabetes compared to controls. This study investigated CHB prevalence across different diabetes types in China.

Area of Science:

  • Hepatology
  • Endocrinology
  • Epidemiology

Background:

  • The association between chronic hepatitis B virus infection (CHB) and specific diabetes mellitus subtypes remains largely uncharacterized.
  • Understanding these associations is crucial for public health strategies and patient management.

Purpose of the Study:

  • To investigate the prevalence of CHB in different diabetes subtypes within a Chinese population.
  • To compare CHB prevalence between patients with type 2 diabetes, adult-onset autoimmune diabetes, and non-diabetic controls.

Main Methods:

  • A cross-sectional study involving 381 patients with adult-onset autoimmune diabetes, 1,365 patients with type 2 diabetes, and 1,365 controls.
  • Exclusion criteria included hepatitis C virus positivity, hepatic cirrhosis, malignancy, and severe renal dysfunction.
  • Patients were categorized based on hepatitis B virus status (negative vs. CHB).

Main Results:

  • Type 2 diabetes patients exhibited a significantly higher CHB prevalence (13.5%) compared to controls (10.0%, P = 0.004).
  • This association persisted even in patients with normal hepatic function (13.3% vs. 8.8%, P = 0.002).
  • No significant difference in CHB prevalence was observed between adult-onset autoimmune diabetes patients and controls.

Conclusions:

  • Chronic hepatitis B virus infection is more prevalent in individuals with type 2 diabetes compared to those with adult-onset autoimmune diabetes and the general population in China.
  • Further research is warranted to elucidate the causal relationship: whether CHB increases type 2 diabetes risk or vice versa.
  • The findings suggest a potential link between type 2 diabetes and CHB, distinct from adult-onset autoimmune diabetes.
Abstract

Keywords:
Adult-onset autoimmune diabetesHepatitis B virusType 2 diabetes

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