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Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric

Resham J Banga1, Sai Archana Krovi1, Suguna P Narayan1

  • 1Department of Chemical and Biological Engineering, ‡Department of Biomedical Engineering, §Department of Chemistry, and ⊥International Institute of Nanotechnology, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.

Biomacromolecules
|December 10, 2016
PubMed

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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