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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
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Assessing cognitive functioning in ALS: A focus on frontal lobe processes.

S M Gillingham1,2, Y Yunusova3,4, A Ganda4,5

  • 1a Rotman Research Institute at Baycrest , Toronto , Canada.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|December 10, 2016
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) often involves cognitive issues. A new test, the ALS-CFB, revealed frontal lobe dysfunction in energisation and executive functions in ALS patients, unlike standard tests.

Keywords:
ALS-CFBAmyotrophic lateral sclerosiscognitionfrontal lobeslongitudinal

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Over 50% of ALS patients experience cognitive deficits beyond motor neuron symptoms.
  • Accurate assessment of these cognitive deficits is challenging due to disease-related barriers and test limitations.

Purpose of the Study:

  • To assess extramotor frontal cognitive functioning in ALS patients.
  • To track changes in these cognitive functions over time as the disease progresses.
  • To identify a specific cognitive profile associated with ALS neurodegeneration.

Main Methods:

  • Developed the Computerised Frontal Battery (ALS-CFB), a modified assessment for ALS.
  • Tested 20 ALS participants and 36 healthy controls.
  • Re-tested a subset of participants (11 ALS, 20 controls) after approximately nine months.

Main Results:

  • Standard screening tests failed to differentiate ALS patients from controls.
  • The ALS-CFB identified a distinct profile of extramotor frontal dysfunction in ALS.
  • This dysfunction specifically involved energisation and executive functions.

Conclusions:

  • The ALS-CFB is a sensitive tool for detecting frontal cognitive deficits in ALS.
  • The identified cognitive profile may reflect the underlying neurodegeneration in ALS.
  • This finding aids in understanding the full spectrum of ALS pathology.