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Related Concept Videos

Second-Order Circuits01:17

Second-Order Circuits

4.1K
Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
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Two Force Member01:30

Two Force Member

1.9K
The equilibrium of a two-force body is a particular case that is often encountered in practical applications. A two-force body is a rigid body that is subjected to only two external forces. For such a body to be in equilibrium, the two forces must have the same magnitude, the same line of action, and the opposite direction.
1.9K
SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

12.3K
In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
12.3K
SN2 Reaction: Kinetics02:14

SN2 Reaction: Kinetics

10.5K
Kinetic Studies and Significance
In a chemical reaction, a relationship exists between the concentration of reactants and the rate at which the reaction proceeds. The study to measure this relationship is known as the kinetics of a chemical reaction. Kinetic studies are used to deduce the rate law of a chemical reaction, which provides information about the species involved during the transition state of the rate-determining step. Thus, kinetic studies help to derive the mechanism of a...
10.5K
SN2 Reaction: Mechanism02:27

SN2 Reaction: Mechanism

18.1K
The kinetic studies of SN2 reactions suggest an essential feature of its mechanism: it is a single-step process without intermediates. Here, both the nucleophile and the substrate participate in the rate-determining step.
The presence of the more electronegative halogen in the substrate creates a polarized carbon-halide bond. The halide pulls the electron cloud generating an electrophilic center at the carbon atom. Thus, the carbon atom carries a partial positive charge while the halide has a...
18.1K
SN2 Reaction: Transition State02:26

SN2 Reaction: Transition State

12.5K
An SN2 reaction of an alkyl halide is a single-step process in which bond formation between the nucleophile and the substrate and bond breaking between the substrate and the halide occurs simultaneously through a transition state without forming an intermediate.
When the nucleophile approaches the electrophilic carbon with its lone pairs, the halide acts as a leaving group and moves away with the electron-pair bonded to the carbon. Dotted partial bonds represent the bonds being formed or broken...
12.5K

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In Vitro Scratch Assay to Demonstrate Effects of Arsenic on Skin Cell Migration
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In Vitro Scratch Assay to Demonstrate Effects of Arsenic on Skin Cell Migration

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In reply 2

M J Maze1, J Paynter2, W Chiu3

  • 1Department of Respiratory Medicine, Auckland District Health Board, Auckland, Centre for International Health, University of Otago, Dunedin.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 10, 2016
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No abstract available in PubMed .

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