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Risk factor profile of calcific aortic stenosis

I Sathyamurthy1, Shaji Alex2, K Kirubakaran3

  • 1Department of Cardiology, Apollo Main Hospital, Chennai, India.

Indian Heart Journal
|December 10, 2016
PubMed

Insights

Calcific aortic stenosis (CAS) patients with coronary artery disease (CAD) have a higher prevalence of diabetes, hypertension, dyslipidemia, smoking, and family history. Diabetes was the only statistically significant difference observed between groups.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Public Health

Background:

  • Calcific aortic stenosis (CAS) and coronary artery disease (CAD) share common risk factors.
  • Previous studies on statin use for CAS progression yielded inconsistent results.

Purpose of the Study:

  • To compare the prevalence of cardiovascular risk factors in patients with calcific aortic stenosis (CAS) with and without associated coronary artery disease (CAD).

Main Methods:

  • 110 patients over 40 with CAS underwent clinical, biochemical, and echocardiographic evaluation.
  • Coronary angiograms were performed in 66% of patients.

Main Results:

  • Patients with CAS and CAD exhibited higher rates of diabetes (65% vs. 30%), hypertension (52% vs. 43%), dyslipidemia (69% vs. 52%), smoking (24% vs. 18%), and family history of CAD (34% vs. 16%).
  • Obesity was more prevalent in patients without CAD (30% vs. 20%).

Conclusions:

  • Diabetes mellitus was the only risk factor with a statistically significant difference between CAS patients with and without CAD.
  • Findings highlight the significant overlap in risk factors between CAS and CAD, emphasizing the need for comprehensive cardiovascular risk management.
Abstract

Keywords:
AtherosclerosisCoronary artery diseaseDegenerative aortic stenosis

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