Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative
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Updated: Aug 14, 2026
The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation
Published on: July 22, 2019
Nicola Veronese1,2, Brendon Stubbs3,4,5, Marco Solmi2,6,7
1Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
Background:
osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence.
Objective:
to determine whether OA was associated with an increased odds of developing depressive symptoms.
Design:
longitudinal cohort study (follow-up: 4.2 years).
Setting:
data were gathered from the North American Osteoarthritis Initiative (OAI) dataset.
Subjects:
people at higher risk developing OA.
Methods:
OA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after 4 years.
Results:
a total of 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (odds ratio (OR): 1.26; 95% confidence of interval (CI): 0.95-1.67). However, multi-site OA (i.e. OA ≥2 sites; OR: 1.48, 95% CI: 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA.
Conclusions:
this is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden.
