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Related Experiment Video

Updated: Mar 10, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
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Functional brain alterations in anorexia nervosa: a scoping review.

Tone Seim Fuglset1, Nils Inge Landrø2, Deborah Lynn Reas3

  • 1Regional Department for Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, Ullevål, Oslo, Norway.

Journal of Eating Disorders
|December 10, 2016
PubMed
Summary

Functional magnetic resonance imaging (fMRI) studies reveal altered brain activation in anorexia nervosa (AN). Research highlights changes in fronto-striatal and limbic circuits, crucial for AN pathophysiology.

Keywords:
Anorexia nervosaFunctional magnetic resonance imagingScoping review

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Area of Science:

  • Neuroimaging research
  • Brain imaging techniques

Background:

  • Anorexia nervosa (AN) is associated with identifiable brain abnormalities.
  • Neuroimaging, particularly functional magnetic resonance imaging (fMRI), is key to understanding these alterations.
  • Research on fMRI in individuals with AN or recovered from AN (AN-REC) is expanding.

Purpose of the Study:

  • To conduct a scoping review of recent research on fMRI in AN and AN-REC.
  • To map the scope and nature of fMRI studies in AN populations.
  • To identify trends and findings in the field between 2010 and 2015.

Main Methods:

  • Systematic literature search of PubMed, Psychinfo, and Embase databases.
  • Included studies published in English between 2010-2015 using "anorexia nervosa" and "functional magnetic resonance imaging" keywords.
  • Analyzed 49 fMRI studies comparing individuals with AN/AN-REC to healthy controls, irrespective of experimental design.

Main Results:

  • Significant heterogeneity observed across studies due to methodological variations.
  • Consistent findings suggest altered activation patterns in specific brain circuits.
  • Key regions implicated include the fronto-striatal and limbic circuits.

Conclusions:

  • Despite variability, studies indicate altered brain activation in fronto-striatal and limbic regions in AN.
  • These circuits are considered vital in the underlying pathophysiology of anorexia nervosa.
  • fMRI research provides valuable insights into the neural basis of AN.